This study shows that leptin promotes lipid storage in Sertoli cells by increasing lipid droplets and triglyceride levels through PI3K/AKT, mTORC1/p70S6K, and PPARγ signaling pathways. These findings highlight a novel role for leptin in testicular energy metabolism and suggest its importance in supporting fatty acid demands during sperm development.
Cita: Dasso ME, Centola CL, Tabares FN, Galardo MN, Meroni SB, Riera MF. Leptin increases lipid storage in Sertoli cells: Signaling pathways and cellular mechanisms involved. Biochimie. 2026 Apr;243:59-69. doi: 10.1016/j.biochi.2026.01.009.
Instagram: cedie.conicet
Sitio web Facebook: cedie.conicet
LinkedIn: https://www.linkedin.com/company/cedie-conicet
