Leptin increases lipid storage in Sertoli cells: Signaling pathways and cellular mechanisms involved.
This study shows that leptin promotes lipid storage in Sertoli cells by increasing lipid droplets and triglyceride levels through PI3K/AKT, mTORC1/p70S6K, and PPARγ signaling pathways. These findings highlight a novel role for leptin in testicular energy metabolism and suggest its importance in supporting fatty acid demands during sperm...