Pathophysiological and Clinical Aspects of Gonadal Development


The objectives of our group are to understand the mechanisms that regulate the development of the gonads during fetal and postnatal life, to understand the pathophysiology of anomalies of the hypothalamic-pituitary-gonadal axis and to make contributions to their diagnosis and management.


Main projects

  1. Molecular androgen-dependent mechanisms underlying pubertal maturation of the testis.
  2. Oestrogen-dependent molecular mechanisms underlying AMH regulation in the testis.
  3. Relevance of Human FSH Carbohydrates on the Regulation of Sertoli Cell Function in Development.
  4. Early diagnosis of central hypogonadism in males.
  5. Effects of cancer treatment on somatic gonad cells in childhood and puberty.
  6. Correlation between ultrastructural phenotype and steroidogenic capacity of hiPSC cells.
  7. Phenotype-genotype correlation in spermatic pathologies of genetic origin.


Staff members

Rodolfo REY, MD, PhD (contact:

Romina GRINSPON, MD, PhD (contact:

Mariela URRUTIA, PhD (contact:

Héctor CHEMES, MD, PhD (contact:

Patricia BEDECARRÁS, MSc (contact:

Marcela VENARA, MD, PhD (contact: