Pathophysiological and Clinical Aspects of Gonadal Development


 

Our group intends to understand the mechanisms regulating the development of the gonads during foetal and postnatal life. It also intends to understand the pathophysiology of the hypothalamic-pituitary-gonadal axis abnormalities and to contribute to diagnosis and management.

 

Main projects

  • Molecular androgen-dependent mechanisms underlying pubertal maturation of the testis.
  • Oestrogen-dependent molecular mechanisms underlying AMH regulation in the testis.
  • Relevance of Human FSH Carbohydrates on the Regulation of Sertoli Cell Function in Development.
  • Early diagnosis of central hypogonadism in males.
  • Cancer treatment effects on somatic gonad cells in childhood and puberty.
  • Correlation between ultrastructural phenotype and steroidogenic capacity of hiPSC cells.
  • Phenotype-genotype correlation in genetic spermatic pathologies.

 

Staff members

Rodolfo REY, MD, PhD (contact: rodolforey@cedie.org.ar)

Romina GRINSPON, MD, PhD (contact: rgrinspon@cedie.org.ar)

Mariela URRUTIA, PhD (contact: murrutia@cedie.org.ar)

Héctor CHEMES, MD, PhD (contact: hchemes@cedie.org.ar)

Patricia BEDECARRÁS, MSc (contact: pbedecarras@cedie.org.ar)

Marcela VENARA, MD, PhD (contact: mvenara@cedie.org.ar)