Growth Factors and Tumor Biology
Goals
We are interested in the basic and clinical aspects of endocrine tumor progression or other cell lines diagnosed in paediatric patients. We study how the Insulin-like Growth Factor (IGFs) system participates in the onset and progression of adrenal medulla tumors (pheochromocytomas) weather associated or not with genetic diseases and in Central Nervous System tumors in paediatric patients. We also study IGFs prognostic value in these pathologies.
Main projects
- Insulin-like Growth Factor (IGFs) system in central nervous system tumours in paediatric patients.
- IGF-1 receptor type 1 (IGF-1R) and brachyury transcription factor (brachy) expresion in paediatric thyroid nodular disease: basic and clinical studies.
- Molecular markers in paediatric CNS tumours. Their importance as diagnostic tools, their prognostic value and therapeutic opportunities.
Staff members
CEDIE Collaborators
National Collaborators
Marcelo Marti: IQUIBICEN, INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CIENCIAS EXACTAS Y NATURALES [CONICET]
Maria del Rosario Gonzalez Baró: INIBIOLP, INSTITUTO DE INVESTIGACIONES BIOQUIMICAS DE LA PLATA "PROF. DR. RODOLFO R. BRENNER" [CONICET]
Fernando Dominici: IQUIFIB, INSTITUTO DE QUIMICA Y FISICOQUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI" [CONICET]
Mercedes García Lombardi: Oncohematology Service. Hospital de Niños Ricardo Gutiérrez.
Martín Medin: Division of Pathology. Hospital de Niños Ricardo Gutiérrez.
Sandra Colli: Division of Pathology. Hospital de Niños Ricardo Gutiérrez.
Elena De Matteo: Division of Pathology. Hospital de Niños Ricardo Gutiérrez.
International Collaborators
Luca Persani: Department of Medical Biotechnology and Translational Medicine, School of Medicine, University of Milan, Milan, Italy. Postgraduate School of Endocrinology and Metabolic Diseases at the University of Milan, Milan, Italy. Division of Endocrine and Metabolic Diseases & of the Lab of Endocrine and Metabolic Research, IRCCS Istituto Auxologico Italiano, Milan. Italy.
Claudio Giacomozzi: Carlo Poma Hospital. Mantova, Italy.
Claudia Palena: LABORATORY OF TUMOR IMMUNOLOGY & BIOLOGY, NCI (National Cancer Institute), NIH-National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. USA.