Ovary Biology


Monitoring as well as improving the efficacy and safety of therapies designed to regulate fertility in women, such as contraception and assisted reproductive technologies (ART), has become an important public health activity.

Cytokines and chemokines, like MCP1 (Monocyte chemoattractant protein 1), are commonly elevated in disorders with a state of chronic low-grade inflammation; including PCOS, and metabolic disorders such as obesity and type 2 diabetes. These disorders are frequently associated with reproductive abnormalities including menstrual disorders, and infertility.

 

Main Projects

  • Determine whether the inhibition or stimulation of CCR2 (C-C motif chemokine receptor 2) signaling influences primordial follicle activation.
  • To study the involvement of CCR2 signaling in oocyte maturation and C-OE (cumulus-oocyte expansion).
  • To assess possible crosstalk/interaction between EGFR (Epidermal Growth Factor Receptor) and CCR2 signaling within the cumulus-oocyte complex (COC).
  • Assess the effects of CCR2 signaling inhibition or stimulation on luteolysis.

 

Staff members

Marina C. PELUFFO, PhD (contact: mpeluffo@cedie.org.ar)

Julieta L. ROJO (contact: jrojo@cedie.org.ar)

Eduardo DASCAL (contact: edascal@cedie.org.ar)