Metabolites in Gonadal Pathophysiology
Since the beginning, this laboratory has been interested in the study of several metabolites involved in the normal performance of the testicular function. Among them, the role of lactate as the main source of energy for germ cells and the molecular mechanisms involved in the regulation of its production by the Sertoli cell is highlighted. Likewise, the action of lactate as a metabolite responsible for signaling in germ cells has been analyzed. Adenosine has also been studied as a molecule that manifests a low energy content in the seminiferous tubule, and it evokes signals that trigger biochemical mechanisms in the Sertoli cell aimed at restoring the energy balance in the germ cells. Currently, the laboratory is focused on the analysis of the participation of glycolysis and glutaminolysis in FSH regulation of Sertoli cell proliferation.
Main projects
Role of glycolysis and reductive glutaminolysis/carboxylation in FSH regulation of immature Sertoli cell proliferation.
Staff members
Collaborators
Nicolás Octavio Favale: Cátedra de Biología Celular y Molecular de la Facultad de Farmacia y Bioquímica (UBA), Argentina.