Gonadal Cell Biology


Our group intends to generate new knowledge about the molecular mechanisms involved in the proper functioning of the testis leading to normal spermatogenesis. The final objective is to contribute to understanding male gonadal axis pathologies that cannot be otherwise explained with currently available information.

 

Main projects

  • Role of SIRT1 in arresting immature Sertoli cell proliferation and in regulating differentiated functions.
  • Deleterious effects of environmental toxins on the proliferation and maintenance of Sertoli cells’ differentiated functions.
  • Effects of metformin on the proliferation and energy metabolism of Sertoli cells and the possible molecular mechanisms involved.
  • Effects of leptin and adiponectin on Sertoli cell proliferation and differentiated functions.
  • Hormonal regulation of molecular mechanisms involved in Sertoli cells lipid metabolism.
  • Study of Sestrin expression in the testis and their participation in the response to Sertoli cell metabolic stress factors.

 

Staff members

Silvina MERONI

María Fernanda RIERA

Marina DASSO

 

CEDIE Collaborators

María Noel GALARDO

Cecilia CENTOLA

Eliana PELLIZZARI

María del Carmen CAMBEROS

 

National Collaborators

Mariano Buffone: Instituto de Biología y Medicina Experimental (IBYME-CONICET), Argentina.