Gonadal Cell Biology


 

Our group intends to generate new knowledge about the molecular mechanisms involved in the proper functioning of the testis leading to normal spermatogenesis. The final objective is to contribute to the understanding of male gonadal axis pathologies that cannot be otherwise explained with currently available information.

 

Main projects

  • Role of SIRT1 in arresting immature Sertoli cell proliferation and in regulating differentiated functions.
  • Deleterious effects of environmental toxins on the proliferation and maintenance of Sertoli cells’ differentiated functions.
  • Effects of metformin on the proliferation and energy metabolism of Sertoli cells and the possible molecular mechanisms involved.
  • Role of glycolysis and reductive glutaminolysis/carboxylation in FSH regulation of immature Sertoli cell proliferation.
  • Effects of leptin and adiponectin on Sertoli cell proliferation and differentiated functions.
  • Hormonal regulation of molecular mechanisms involved in Sertoli cells lipid metabolism.
  • Study of Sestrin expression in the testis and their participation in the response to Sertoli cell metabolic stress factors.

Staff members

Silvina MERONI, PhD (contact: smeroni@cedie.org.ar)

María Fernanda RIERA, PhD (contact: friera@cedie.org.ar)

María Noel GALARDO, PhD (contact: mngalardo@cedie.org.ar)

Gustavo RINDONE, PhD

Agostina GORGA, MSc

Cecilia CENTOLA, MSc

Eliana PELLIZZARI, PhD (contact: epellizzari@cedie.org.ar)

María del Carmen CAMBEROS, PhD (contact: mccamberos@cedie.org.ar)