Gonadal Cell Biology
Our group intends to generate new knowledge about the molecular mechanisms involved in the proper functioning of the testis leading to normal spermatogenesis. The final objective is to contribute to understanding male gonadal axis pathologies that cannot be otherwise explained with currently available information.
Main projects
- Role of SIRT1 in arresting immature Sertoli cell proliferation and in regulating differentiated functions.
- Deleterious effects of environmental toxins on the proliferation and maintenance of Sertoli cells’ differentiated functions.
- Effects of metformin on the proliferation and energy metabolism of Sertoli cells and the possible molecular mechanisms involved.
- Effects of leptin and adiponectin on Sertoli cell proliferation and differentiated functions.
- Hormonal regulation of molecular mechanisms involved in Sertoli cells lipid metabolism.
- Study of Sestrin expression in the testis and their participation in the response to Sertoli cell metabolic stress factors.
Staff members
CEDIE Collaborators
National Collaborators
Mariano Buffone: Instituto de Biología y Medicina Experimental (IBYME-CONICET), Argentina.