Cushing’s syndrome (CS) constitutes one of the most challenging diagnostic assessments for paediatric endocrinologists. The clinical presentation of some children with exogenous obesity overlaps with those observed in hypercortisolism states. Accurate, noninvasive first-line tests are necessary to avoid falsepositive results in the obese. We aimed to evaluate the diagnostic accuracy of salivary cortisol to assess endogenous hypercortisolism in children with obesity and clinical overlapping signs of CS.
Cita: María Gabriela Ballerini, Analía Verónica Freire, María Eugenia Rodríguez, Luciana Brenzoni, Luciana Daga, Laura Castro, Ana Carolina Arias Cau, Graciela Testa, Melina Gil, Débora Braslavsky, Ana Vieites, Ana Keselman, Ignacio Bergadá, Andrea Josefina Arcari, María Gabriela Ropelato. Nocturnal Salivary Cortisol Is an Accurate Non-Invasive Test to Assess Endogenous Hypercortisolism in Children with Obesity and a Clinical Phenotype Suspicious for Cushing’s Syndrome. Horm Res Paediatr Horm Res Paediatr. 2024 Aug 9:1-9. doi: 10.1159/000540785.
